打粒细胞集落刺激因子（粒细胞集落刺激因子治疗这些失败有效）

作者：Kamath MS翻译：烟台市烟台山医院孙雪艳 （2041138503@qq.com），我来为大家科普一下关于打粒细胞集落刺激因子?以下内容希望对你有帮助!

打粒细胞集落刺激因子

作者：Kamath MS

翻译：烟台市烟台山医院孙雪艳 （2041138503@qq.com）

【摘要】

粒细胞集落刺激因子（G-CSF）是一种糖蛋白，已用于接受辅助生殖技术（ART）的妇女。我们决定进行一项系统性的评估，以评估G-CSF在接受ART的妇女中对于薄型子宫内膜和反复着床失败（RIF）治疗的有效性。

研究结果包括子宫内膜增厚程度、活产、临床妊娠率和不良影响。我们分别设计两个试验评估薄型子宫内膜和RIF的妇女应用G-CSF结局。

虽数据提示薄型子宫内膜患者应用G-CSF后子宫内膜厚度增加无统计学意义，然而，与未进行干预相比，G-CSF组后临床妊娠率显著升高，但这两个结果的证据质量非常低。

在RIF人群中，与没有干预相比，G-CSF组临床妊娠率显著升高，但证据质量低。

目前结果提示G-CSF在治疗薄型子宫内膜和RIF方面有一定效果。然而，这些研究结果需要在更大的试验中进一步验证，才能在常规临床实践中使用G-CSF。

followed by：

LDA with LMWH, LDA plus LMWH plus intravenous immunoglobulin, corticosteroid with LDA and others。

附原文:

Abstract Granulocyte-colony stimulating factor(G-CSF), a glycoprotein, has been used in women undergoing Assisted Reproductive Technology (ART). We decided to undertake a systematic review to evaluate the effectiveness of G-CSF in women with thin endometrium and recurrent implantation failure (RIF) undergoing ART.

The outcomes included an increase in endometrial thickness, live birth, clinical pregnancy rates and adverse effects. We included two trials evaluating women with thin endometrium and another two trials evaluating women with RIF.

The pooled data did not reveal statistically significant increase in endometrial thickness following G-CSF in women with thin endometrium (mean difference 0.47, 95% CI -1.36-2.31; I2.82%). However significantly higher clinical pregnancy rate was noted (RR 2.43, 95% CI 1.09-5.40; I2.0%) followingG-CSFcompared to no intervention and quality of evidence for both these outcomes was very low.

In RIF population, the administration of G-CSF was associated with a significantly higher clinical pregnancy rate compared to no intervention with pooled risk ratio of 2.51 (95% CI 1.36-4.63; I2.0%) and quality of evidence being low. Findings of current review suggest a possible benefit ofG-CSF in women with thin endometrium undergoing ART and RIF. However these findings need to be further validated in larger trials before G-CSF can be used in routine clinical practice.

引自：

Kamath M S, Chittawar P B, Kirubakaran R, et al. Use of granulocyte-colony stimulating factor in assisted reproductive technology: A systematic review and meta-analysis.[J]. Eur J Obstet Gynecol Reprod Biol, 2017, 214:16-24.